dc.contributor.author	BENHAOUA H. BLIZAK H. REMAL O
dc.date.accessioned	2019-03-03T11:13:56Z
dc.date.available	2019-03-03T11:13:56Z
dc.date.issued	2010
dc.description.abstract	Cucurbitacins are tetracyclic titerpenes with a cucurbitane skeleton and higly toxic effects. They were identified in about a hundred specices among the 900 species currently known.They are listed in several categories as glycosylated and non glycosylated cucurbitacins namely A, B, C, D, E … .. etc.. Little are the informations availble on the absorption, metabolism and exretion of the aglycone an glycosylated cucurbitacins. The toxic effects recorded in animals and humans, however, indicate that these compounds are absorbed at least to some extent. This study provides a compilation of most studies published in last ten years on the pharmacological and biological effects of these extremely bitter substances. From these studies, it is clear that exposure of laboratory animals to cucurbitacins can lead to toxic effects However, exposure via the oral route results in less toxic effects than exposure via subcutaneously, intraperitoneally and intravenously voices . The oral LD 50 in mice is low and is about 5 mg/kg bw for some cucurbitacins (cucurbitacin D and I ). The main tixicological effects produced by cucurbitacin D in animals appears to be an increase in capillary permeability, irritation of the intestinal mucosa and an increase in intestional motility .	en_US
dc.identifier.uri	https://repository.univ-msila.dz/handle/123456789/10267
dc.language.iso	fr	en_US
dc.publisher	Université Mohamed BOUDIAF de M'Sila	en_US
dc.subject	Tetracyclic tritepenes , toxicity, metabolism, LD 50 , cucurbitacins	en_US
dc.title	LES CUCURBITACINES STRUCTURE, PROPRIETIE ET TOXICITE	en_US
dc.type	Thesis	en_US

LES CUCURBITACINES STRUCTURE, PROPRIETIE ET TOXICITE

Files

Original bundle

License bundle

Collections