Biological and pharmacological study of Pistacia lentiscus L.
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Date
2025-10-05
Journal Title
Journal ISSN
Volume Title
Publisher
UNIVERSITE MOHAMED BOUDIAF - M’SILA
Abstract
The purpose of this study was to assess the lentisk seed oil from Hodna sub-arid
region obtained by hot and cold extraction methods for the first time in terms of its
physicochemical characteristics, phenolic contents and profile, tocols, and fatty acid
compositions as well as its antimicrobial, antioxidant, wound-healing, and antiinflammatory activities. Compared to the traditional procedure, which produced a
yield of 5%, the cold pressing process produced a much higher yield of 15%. There
are differences in the physicochemical properties of oils produced by hot extraction
(HLHO) and cold pressing (HLCO). The oils are rich in unsaturated fatty acids,
particularly linoleic and oleic acids. The phenolic content of the HLCO was higher
than that of the HLHO. In HLCO, nine polyphenolic compounds were found, with
quercetin and catechin being the most abundant, HLHO was found to contain seven
compounds, with quercetin and sinapic acid being the most prevalent. α-tocopherol
(59.96 mg/kg) and γ-tocopherol (19.64 mg/kg) were the main tocopherols in HLHO
and HLCO, respectively. For HLHO and HLCO, the primary tocotrienols were β-
tocotrienol (8.11 mg/kg) and γ-tocotrienol (8.02 mg/kg), respectively. Both mastic
oils demonstrated the same ability to scavenge DPPH-radicals. There were only minor
inhibitory effects on a panel of eleven microbial species. Both oils exhibited similar
wound healing activity, which was comparable to the standard Cicatryl Bio®.The
results of the anti-inflammatory activity of the phenolic compounds indicated that
these compounds had significant inhibitory effects on COX-2. The method of
extraction and the origin had an impact on the samples' physicochemical
characteristics, phytochemical contents and antioxidant activity. In the food,
cosmetics, and health industries, the investigated oils especially the cold-extracted one
may serve as a natural source of potential bioactive components that may be
substituted for manufactured ones or added to new products.