Phytochemical investigation of the n-BuOH extract of Scilla lingulata using LC-ESI/MS technique, enriched with molecular docking studies
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Date
2020-09
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UNIVERSITE MOHAMED BOUDIAF - M’SILA
Abstract
In this work, we mainly focused on the phytochemical study of the endemic Algerian
species, Scilla lingulata Poir. (Asparagaceae), in order to structurally identify its chemical
composition. The use of the analytical LC-ESI / MS technique, allowed us to investigate the
phytoconstituents, especially the polar compounds, present in the n-butanolic extract of this plant.
Profound analysis in the UV-Vis and ESI / MS spectra (in positive and negative mode) allowed us to
elucidate the structure of ten glycosylated flavonoids (flavone type). The in silico assays of those latter
were carried out by means of molecular docking to evaluate the anti-Alzheimer and anti-inflammatory
activities of these molecules.
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Keywords
n-butanolic extract of Scilla ligulata, UV-Vis, LC-ESI/MS, glycosylated flavonoids, Molecular docking, in silico, Anti-Alzheimer activity, Anti-inflammatory activity.